Oh god he's trotting out the Knuth quote. "Premature optimization is the root of all evil."
I'm not going to ask a field of internet strangers to watch a two hour history lesson by Casey Muratori that ends in a fucking Ginger Bill interview, but that quote did have a context. A complex, nuanced context, where the least damaging summary I can give is "this was based on studying a bunch of really tiny programs that were each basically just a main loop and some setup/teardown." Really closer to things we'd think of as function-scale today. The statistics from that study do not generalize to post-1980 software very well.
But you don't need me to tell you that, to know that the parade of charlatans who have borrowed this quote over my lifetime are the kind of people to blame for the Windows 12 task bar being a React application.